Randomised double-blind, positive-controlled trial to assess the efficacy of glucosamine/chondroitin sulfate for the treatment of dogs with osteoarthritis (2006, The Veterinary Journal)
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Link: https://www.sciencedirect.com/science/article/abs/pii/S1090023306000554
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Benefits claimed: In dogs with confirmed hip or elbow OA, chondroitin sulfate (combined with glucosamine) led to significant improvements in pain, weight-bearing, and overall condition severity after 70 days, with slower onset but comparable efficacy to carprofen by study end. It protects against synovitis, stimulates cartilage metabolism, inhibits degradation, and is well-tolerated for long-term use, enhancing mobility and quality of life.
Glucosamine and chondroitin use in canines for osteoarthritis: A review (2017, Open Veterinary Journal)
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Benefits claimed: Chondroitin sulfate inhibits destructive enzymes in joint fluid/cartilage and supports glycosaminoglycan/proteoglycan synthesis, aiding cartilage formation and joint health in OA-affected dogs (prevalent in 20% of dogs over 1 year). Clinical trials claim symptomatic relief, including reduced pain (up to 51% overall, 48% on manipulation, 43% post-exertion), improved weight-bearing, and better overall condition, with a benign side effect profile (e.g., minor GI issues) for adjunctive therapy.
Efficacy of a dietary supplement in dogs with osteoarthritis: A randomized placebo-controlled, double-blind clinical trial (2022, PLOS ONE)
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Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0263971
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Benefits claimed: As part of a supplement (with glucosamine/hyaluronic acid), chondroitin sulfate significantly alleviates chronic OA pain and clinical signs after 40-60 days, improving mood, reducing lameness, and increasing willingness to move/play/jump per owner/veterinary assessments. It regulates collagen synthesis, inhibits destructive enzymes, and supports joint health without adverse effects, making it a safe option for pain management in dogs.