Interventional study of high dose folic acid in gastric carcinogenesis in beagles (2002, Gut)
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Benefits claimed: High-dose folic acid (20 mg/day for 15 months) significantly reduces the incidence of chemically induced gastric cancer (from 100% in controls to 37.5%), elevates serum and gastric mucosal folate concentrations, and supports chemoprevention by addressing folate deficiency and potential DNA hypomethylation in at-risk dogs.
Plasma Homocysteine Concentrations in Dogs (2014, International Journal of Veterinary Medicine: Research & Reports)
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Link: https://ibimapublishing.com/articles/IJVMR/2014/141449/141449.pdf
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Benefits claimed: While not directly testing supplementation, the study highlights folic acid's role in homocysteine remethylation; elevated homocysteine is linked to skin disease (odds ratio 1.077 per 1 μmol/L increase), suggesting folic acid could reduce hyperhomocysteinemia risks, potentially benefiting dogs with dermatological, cardiovascular, neoplastic, or kidney issues by supporting metabolic pathways.