Anti-inflammatory response of dietary vitamin E and its effects on pain and joint structures during early stages of surgically induced osteoarthritis in dogs (2013, Canadian Journal of Veterinary Research)
-
Benefits claimed: Vitamin E supplementation (400 IU/animal per day for 55 days) reduced pro-inflammatory markers in synovial fluid (e.g., lower NOx and PGE2 concentrations), decreased histological lesions in articular cartilage (e.g., significant reduction in lesion scores on femoral condyles and tibial plateaus), and lowered pain indicators (e.g., trends in reduced VAS and EDA scores), supporting its role in alleviating early OA symptoms and protecting joint integrity.
Vitamin E supplementation in canine atopic dermatitis: Improvement of clinical signs and effects on oxidative stress markers (2014, Veterinary Record)
-
Benefits claimed: At 8.1 IU/kg body weight daily for 8 weeks, it increased plasma vitamin E and total antioxidant capacity (TAC), significantly lowered CADESI-03 scores (measuring dermatitis extent and severity), and improved clinical signs like erythema, lichenification, excoriation, and alopecia, indicating antioxidant effects that enhance skin health and reduce symptoms in dogs with moderate atopic dermatitis.
Effect of dietary antioxidants on free radical damage in dogs and cats (2024, Journal of Animal Science)
-
Link: https://academic.oup.com/jas/article/doi/10.1093/jas/skae153/7686798
-
Benefits claimed: As part of an antioxidant blend (up to 1,500 IU vitamin E/kg diet for 84 days), it increased circulating vitamin E levels, enhanced immune cell protection against oxidation, reduced DNA damage (e.g., higher head DNA retention in Comet assay and lower 8-hydroxy-2ʹ-deoxyguanosine), and improved overall antioxidant status (e.g., linear or quadratic increases in total antioxidant power), promoting immune health and cellular integrity in adult dogs.